The 9 Best Bed Bug Sprays of 2023 (2023)

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The 9 Best Bed Bug Sprays of 2023 (1)

Bed bugs are terrible pests. Although they don’t spread disease, they can cause bite marks that may itch mightily, which could lead to infection if you scratch extensively. They also are notorious for hitching a ride home with you and overstaying their welcome quickly.

We spoke with specialist Ben Hottel, Entomologist with Orkin Pest Control about what to look for in a bed bug spray. Mr. Hottel says, “Bed bugs are extremely resilient, making them difficult to control."
With his insights in mind, we researched dozens of the leading bed bug sprays available online and tested each product on this list.

Our Top Picks

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Best for Large Spaces:

Harris Bed Bug Killer at Amazon

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Best Fast Acting:

Bedlam Plus at Amazon

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(Video) Top 10 Best Bed Bug Sprays 2022 | Video Review | The Guardians Choice

Best Overall

Ortho Home Defense Max Bed Bug Killer


The 9 Best Bed Bug Sprays of 2023 (2)

What We Like

  • Easy to use

  • Wand makes it easy to reach hard-to-access spaces

  • Also kills fleas and ticks

  • Kills bed bugs and eggs

What We Don't Like

  • Need to apply every two weeks

The Ortho Home Defense Max Bed Bug Killer is our best overall choice for treating the earliest signs of bed bugs in your home. This product is a favorite due to the variety of formats you can buy, from the simple aerosol spray to the more economical gallon container, with wand.

The battery-operated wand option makes this product usable just about anywhere, which is one way to lessen the stress of a bed bug infestation. Because it sprays more evenly than other methods, you can cover hard-to-reach areas such as curtain edges, behind mattresses, and under furniture. Made for indoor use, this spray is stain-free and unscented. It can be used directly on visible bugs and eggs. If you continue to see these pests or their eggs, Ortho suggests reapplying every two weeks until they are gone.

It is important to clear the room first before use; as with all insect sprays using chemicals, the chemicals can be harmful to pets and children if ingested.

Price at time of publish: $23

Volume: 1 gallon| Ingredients: 0.250% Bifenthrin, 0.050% Imidacloprid, 0.450% Piperonyl Butoxide| Effectiveness: 2 weeks

Best Budget

EcoVenger Bed Bug Killer Travel Size

The 9 Best Bed Bug Sprays of 2023 (3)

What We Like

  • Affordable

  • Portable size

  • Easy to use

What We Don't Like

  • No wand application

    (Video) ⭕ Top 5 Best Bed Bug Spray 2022 [Review and Guide]

You can kill bed bugs while on the road and still maintain your eco-friendly status with the travel size of EcoVenger's Bed Bug Killer. The small 2-ounce size comes in at under $10 and is perfect for taking with you on vacation. Most bed bug infestations in the home start from bugs coming home with you from other destinations. This spray will help make sure no bugs hitch a ride in your suitcase home.

Comprising essential oils, this mixture kills on contact, keeping you safe while providing excellent results. For those who are looking for a larger size, it also comes in 16-ounce and 128-ounce containers.

Price at time of publish: $8

Volume: 2, 16, or 128 ounces | Ingredients: Generiol, cedar oil| Effectiveness: 2 weeks

Best Spot Treatment

HARRIS Bed Bug Killer

The 9 Best Bed Bug Sprays of 2023 (4)

What We Like

  • Multiple sizes

  • Great for spot treatments

  • Suitable for indoor use

What We Don't Like

  • Toxic (make sure to keep away from children and pets)

If you need to spot treat for bed bugs, Harris’ Pyrethroid Resistant Bed Bug Killer is a great option as it comes in a handy, easy-to-use spray bottle. This highly effective formula is designed to eradicate even the most stubborn of bed bugs that have become resistant to pesticides containing pyrethroids. What sets this bed bug spray apart is the fact that it continues to offer residual protection for up to 16 weeks.

While Harris Pyrethroid Resistant Bed Bug Killer is available in many sizes and formats, we recommend the 32-ounce spray bottle for spot treatments, which is easy to use with one hand. This spray does contain imidacloprid, which is toxic to people and pets, so use with care.

Price at time of publish: $27

Volume: 32 ounces| Ingredients: 3-phenooxybenzyl, n-octyl bicycloheptene dicarboximide, imidacloprid| Effectiveness: 16 weeks

Best for Baseboards

Rockwell CimeXa Insecticide Dust

The 9 Best Bed Bug Sprays of 2023 (5)

What We Like

  • Easy to use

  • Lasts up to ten years

  • Works for any home type

  • Kills a variety of pests

What We Don't Like

  • Application can be tedious

For baseboards, sprays might not be able to provide the layer of penetration you need, and that is when it is time to reach for powder or dust. CimeXa Insecticide Dust is a bed bug powder made from a fine silica powder, which dries out the exoskeletons of bed bugs, eventually killing them.CimeXa can be applied with a paintbrush, and only a thin layer is needed. Keep in mind that you will only need a small amount, as the small particles of silica will attach themselves to bed bugs passing through.

Although the application process can be a bit tedious, you only need to apply CimeXa once, as it can provide up to ten years of effectiveness if applied correctly.

Price at time of publish: $15

Volume: 4 ounces| Ingredients: Silica| Effectiveness: 10 years

The 9 Best Ant Killers of 2023

Best for Large Spaces

Harris Bed Bug Killer Gallon

The 9 Best Bed Bug Sprays of 2023 (6)

What We Like

  • Easy to use

  • Can be used on multiple surfaces

  • Large volume

  • Effective for up to 16 weeks

(Video) Top 10 Bed Bug Trap in 2023 (Best Selling)

What We Don't Like

  • Toxic chemicals

The Harris Bed Bug Killer is essential for anyone who wants to get rid of bed bugs in larger spaces. This 128-ounce formula features a handy wand that will allow you to access hard-to-reach places where the pests may be hiding.

Aside from the size and helpful wand, what sets this product apart is its longevity—Harris claims that, if applied correctly, this product can be effective for up to 16 weeks, so you won't have to worry about reapplying it often, like some other products on this list. The manufacturer also notes that it's best to use this product directly on the bed bugs and their eggs. You can apply it on many different surfaces, including bed frames and the edges, folds, and seams of a mattress, but it should not be applied on bedding, clothing, or pillows.

Price at time of publish: $55

Volume: 128 ounces| Ingredients: 3-phenooxybenzyl, n-octyl bicycloheptene dicarboximide, imidacloprid| Effectiveness: 16 weeks

Deter Pesky Bugs With the Best Bed Bug Mattress Covers

Best for Upholstery

Say Bye Bugs Bed Bug Exterminator

The 9 Best Bed Bug Sprays of 2023 (7)

What We Like

  • Safe on fabric

  • Water-based

  • Odorless

What We Don't Like

  • May need to apply multiple times a day for best results

If spraying toxic chemicals on your clothes and bedding makes you nervous, try the Say Bye Bed Bug Exterminator. This water-based formula degrades the exoskeletons of the bed bugs on contact, leaving your upholstery bed bug free in no time. This handy spray bottle comes in several sizes, including a travel option, and is safe to use on any type of material.

Note that for best results, spray twice a day for a minimum of two weeks while infestation occurs. This spray leaves no odor and does not stain.

Price at time of publish: $69 for 3-pack

Volume: 16 ounces| Ingredients: Sodium lauryl sulfate, sodium chloride, and citric acid| Effectiveness: Up to 2 weeks

Best Eco-Friendly

Eco Defense Bed Bug Killer

The 9 Best Bed Bug Sprays of 2023 (8)

What We Like

  • Large size covers large area

  • Plant-based ingredients

  • Easy to read instructions

What We Don't Like

  • Must be in direct contact with insects to be effective

If you are concerned about harsh chemicals and are looking for an environmentally friendly option, Eco Defense Bed Bug Killer is easy to find and use. This bed bug spray has a natural formula and is non-staining. If you have pets or small children at home, you will appreciate the fact that Eco Defense Bed Bug Killer does not contain pesticides that are considered toxic.

While the formula does have a noticeable scent due to plant oils, we found it pleasant while testing, especially when compared to chemical-based pesticides. Eco-defense bed bug killer only kills on contact, so best results are seen through a combination of tactics, such as proper sanitation.

Price at time of publish: $60

Volume: 1 gallon| Ingredients: Plant-based oils| Effectiveness: 2 weeks

Best Fast Acting

Bedlam Plus

The 9 Best Bed Bug Sprays of 2023 (9)

(Video) 10 Best Bed Bug Sprays 2020

What We Like

  • Easy to use

  • Works on most surfaces

  • Fast-acting

What We Don't Like

  • Toxic chemicals for pets and people

If bed bugs have invaded your space, and you want to get rid of them quickly, Bedlam Plus is an excellent option. Bedlam is one of the oldest names in the business of busting bed bugs, and this water-based spray is safe for most surfaces, including your mattress. It also will not stain your upholstery and does not leave behind a lingering scent.

The Bedlam Plus spray will kill bed bugs on contact and has up to two weeks of residual killing power. Like many options on this list, it is toxic and should be kept out of reach.

Price at time of publish: $29

Volume: 17 ounces| Ingredients: Phenoxybenzyl dimethyl, cyclopropanecarboxylate, N-Octyl bicycloheptene dicarboximide, imidacloprid | Effectiveness: 2 weeks

Best Smelling

MDX Concepts Bed Bug Killer

The 9 Best Bed Bug Sprays of 2023 (10)

What We Like

  • Can be used indoors and out

  • Pleasant scent

  • Plant-based formula

What We Don't Like

  • Only kills when bugs come in direct contact with spray

While scent might be far from your mind when you're seeking a bed bug treatment, you may consider the pleasing candy-cane scent from MDX concepts a bonus! Featuring a plant-based formula containing peppermint oil, this spray can be used both indoors and outdoors. In addition to killing bugs on contact, it also acts as a repellent, keeping future infestations at bay.

This formula is safe to use on any surface, works quickly, and is safe around pets and kids. For best results, be sure to clean the room before spraying.

Price at time of publish: $30

Volume: 16 ounces| Ingredients: Plant oils| Effectiveness: 2 weeks

Final Verdict

If you are searching for a fast-acting, easy-to-use bed bug spray, pick up the Ortho Home Defense Max Bed Bug Killer. We appreciate that it can also kill fleas and ticks. For a more budget-friendly or travel-size solution, we recommend the EcoVenger Bed Bug Killer Spray, which is made of essential oils and can kill bed bugs on contact.

What to Look for in a Bed Bug Spray


To get the upper hand on a bed bug infestation, most sprays are formulated with powerful insecticides. However, you should avoid pyrethroids, as those are no longer considered effective treatments on their own against bed bugs. Look for bed bug sprays that have gone through recent periods of testing and have published research you can review. You should always take precautions to protect children and pets, and if that is a concern, bed bug sprays that feature plant-based ingredients might make more sense for you. Usually relying on aromatic oils, these will only work when they make direct contact with the insect, though some offer repellent action.


As soon as you pull the trigger, bed bug sprays go to work. When an insect encounters the spray, it will either be killed immediately or spread the treatment to its relatives if it’s a residual formula. The effectiveness refers to its ability to remain active after use. For most, the effective window is about two weeks, with some, like the dust discussed above, lasting years.

Contact vs. Residuals

Bed bug sprays are typically sold as either contact or residual formulas.

Contact bed bug spray, as the name suggests, kills when it encounters a bed bug directly. This type works best on areas that you are sure have bed bug activity. Most are effective for two weeks, but remember that they need to physically touch bugs to do their job.

Residual bed bug sprays are your best bets for larger infestations or if you have no idea where the bed bugs are currently residing. The bugs are not instantly killed by the treatment and are more likely to spread it slowly to other members of their group. Residual does mean that you might have to wait longer for results, but it will still help lessen the severity of your infestation.


  • Do bed bug sprays really work?

    Bed bug sprays are only as effective as the method of application. Be sure to read directions and note that reapplication might be required for certain products. Most advise a little extra effort on your end, in terms of cleaning rooms and moving furniture to help limit bed bug mobility. Most sprays work by coming in direct contact with bed bugs, so your aim is important, too. For best results, make sure to target areas where you are sure there is current activity.

  • What causes bed bugs?

    Bed bugs are professional hitchhikers, with the females requiring the protein found in a blood-based meal to produce eggs. They do not occur naturally in the home and come from somewhere else, with hotels, hostels, and used mattresses being common culprits. Bed bugs can taxi in on your clothes, your luggage, and just about any other upholstery you own. Carrying a travel-size bed bug spray can be a great way to avoid any stowaways.

  • Can bed bugs survive the washing machine?

    Just washing your linens is not enough to ensure that bed bugs will not remain. Heat is by far one of the most effective ways to get rid of bugs of any kind quickly, so a trip through the dryer will ensure that you get them all.

    If you do not have a dryer, set your washing machine to the highest temperature it goes to (140 degrees is optimal) for best results.

Why Trust The Spruce?

This article was written by Amanda Rose Newton, a freelance writer for The Spruce. As an entomologist, she is always on the lookout for effective, safe, and easy to use insecticides to recommend to friends and family. To prepare this roundup, Amanda Rose tested each product for ease of use, functionality, and accuracy. She also reached out to Ben Hottel, an entomologist with Orkin Pest Control, for further insights.

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